Nottingham Covid Research Group Focus

The focus of the Nottingham CRG is:

1. Define whether SARS-CoV-2 gains entry to alveolar epithelium using a second receptor (eg Integrins) as well as, or instead of ACE2.

2. Determine whether soluble ACE2 facilitates, or inhibits alveolar uptake of SARS-CoV-2.

3. Determine the expressionlevels of ACE2 and potential co-receptors (eg integrins) in the alveoli in a range of diseases at various times throughout the life course.

4. Review the evidence that drugs which have the potential to protect the alveoli from a ‘cytokine’ storm might be useful therapies for severe Covid disease.

5. Determine the long term consequences of alveolar damage in Covid-19 related ARDS on the development of progressive pulmonary fibrosis.