Nottingham Covid Research Group
The Nottingham Covid Research Group started in February 2020 to investigate the pathogenesis, treatment and complications of lung disease caused by the SARS-CoV-2 virus.
SARS-CoV-2 emerged in Wuhan China in late 2019 causing widespread respiratory disease which spread throughout the world and developed into a Global Pandemic by March 2020.
As of March 26th 2020 nearly half a million confirmed cases and over 20,000 deaths, and the vast majority of deaths are due to viral pneumonia leading to Acute Respiratory Distress Syndrome (ARDS).
The SARS-CoV-2 virus uses the Angiotensin Converting Enzyme 2 (ACE2) receptor to gain cell entry, and once inside the cell the virus replicates leading to infection and cell death. However, most people who are infected do not get severe disease, and fewer still develop ARDS.
Therefore, understanding why some people develop ARDS and others don’t is crucial to developing strategies to prevent the development of ARDS, limiting healthcare resource requirement and reducing mortality from Covid-19.